Jing Wang, Billy T Dye, Kanagalaghatta R Rajashankar, Igor Kurinov, Brenda A Schulman

SUMMARY: The multisubunit anaphase promoting complex (APC) is an essential cell-cycle regulator. Although CDC26 is known to have a role in APC assembly, its molecular function has remained unclear. Biophy

Nature Structural & Molecular Biology 16, 987-989 Brief Communication

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Jed J W Wiltzius, Meytal Landau, Rebecca Nelson, Michael R Sawaya, Marcin I Apostol, Lukasz Goldschmidt, Angela B Soriaga, Duilio Cascio, Kanagalaghatta Rajashankar, David ...

SUMMARY: In prion inheritance and transmission, strains are phenotypic variants encoded by protein 'conformations'. However, it is unclear how a protein conformation can be stable enough to endure transmi

Nature Structural & Molecular Biology 16, 973-978 Article

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Tomoko Kawamata, Hervé Seitz, Yukihide Tomari

SUMMARY: MicroRNAs (miRNAs) regulate expression of their target mRNAs through the RNA-induced silencing complex (RISC), which contains an Argonaute (Ago) family protein as a core component. In Drosophila

Nature Structural & Molecular Biology 16, 953-960 Article

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Firaz Mohideen, Allan D Capili, Parizad M Bilimoria, Tomoko Yamada, Azad Bonni, Christopher D Lima

SUMMARY: Phosphorylation and small ubiquitin-like modifier (SUMO) conjugation contribute to the spatial and temporal regulation of substrates containing phosphorylation-dependent SUMO consensus motifs (PD

Nature Structural & Molecular Biology 16, 945-952 Article

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Sandra M G Dias, Kristin F Wilson, Katherine S Rojas, Andre L B Ambrosio, Richard A Cerione

SUMMARY: The binding of capped RNAs to the cap-binding complex (CBC) in the nucleus, and their dissociation from the CBC in the cytosol, represent essential steps in RNA processing. Here we show how the n

Nature Structural & Molecular Biology 16, 930-937 Article

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Michael G Poirier, Eugene Oh, Hannah S Tims, Jonathan Widom

SUMMARY: The packaging of eukaryotic DNA into chromatin sterically occludes polymerases, recombinases and repair enzymes. How chromatin structure changes to allow their actions is unknown. We constructed

Nature Structural & Molecular Biology 16, 938-944 Article

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Patricia Landry, Isabelle Plante, Dominique L Ouellet, Marjorie P Perron, Guy Rousseau, Patrick Provost

SUMMARY: Platelets have a crucial role in the maintenance of hemostasis as well as in thrombosis and vessel occlusion, which underlie stroke and acute coronary syndromes. Anucleate platelets contain mRNAs

Nature Structural & Molecular Biology 16, 961-966 Article

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Miguel Garcia-Diaz, Katarzyna Bebenek, Andres A Larrea, Jody M Havener, Lalith Perera, Joseph M Krahn, Lars C Pedersen, Dale A Ramsden, Thomas A Kunkel

SUMMARY: Family X polymerases such as DNA polymerase λ (Pol λ) are well suited for filling short gaps during DNA repair because they simultaneously bind both the 5′ and 3|[prime]

Nature Structural & Molecular Biology 16, 967-972 Article

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Nova Fong, Marie Öhman, David L Bentley

SUMMARY: We investigated whether a continuous transcript is necessary for co-transcriptional pre-mRNA processing. Cutting an intron with the fast-cleaving hepatitis δ ribozyme, but not the slower

Nature Structural & Molecular Biology 16, 916-922 Article

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Hyonchol Jang, Soo-Youn Choi, Eun-Jung Cho, Hong-Duk Youn

SUMMARY: The tumor suppressor p53 has been proposed to bind target promoters upon genotoxic stress. However, recent evidence shows that p53 occupies some target promoters without such stress, suggesting t

Nature Structural & Molecular Biology 16, 910-915 Article

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